ABSTRACT
Background: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), which causes coronavirus disease 2019 (COVID-19), has swiftly grown into a pandemic. Despite extensive research, the function of numerous haematological and biochemical markers in prognosis remains unknown. There have been scientific papers in the Indian setting that describe demographics, clinical characteristics, hospital course, morbidity, and death in COVID-19 patients, however the numbers are limited. The current study provided us with a better understanding of the disease development and progression in COVID-19 patients, as well as the factors that determine disease severity. Method(s): This study was carried out at a COVID-19 tertiary care facility at Dr. D. Y Patil Medical College, Hospital and Research Centre, Pune. The demographic and clinical information, laboratory parameters of admitted COVID-19 patients were collected were subsequently analysed. Result(s): The mean (SD) age of COVID 19 patients was 48.21(16.37) years. The total number of COVID-19 patients with mild disease was 273 (45.27%), moderate disease was 177 (29.35%), and severe disease was 153 (25.37%). The Serum urea, serum AST, Serum total bilirubin, Serum Conjugated Bilirubin, Serum Unconjugated bilirubin, serum LDH, Serum CRP and Serum Ferritin were differ significantly between mild, moderate, and severely ill COVID-19 cases. Conclusion(s): In conclusion the study revealed the role of numerous biochemical indicators in the severity of COVID-19, as well as the order of effectiveness among the markers. Our findings suggested that LDH and CRP levels were a promising biomarker for predicting COVID-19 severity. Copyright © 2022 Ubiquity Press. All rights reserved.
ABSTRACT
Natural Killer (NK) cells are the key lymphocyte subset of the natural immune system that arbitrates antiviral and anticancer responses. In the human body NK cells inhabit in the bone marrow, lymph nodes, tonsils, skin, liver, gut, and lungs. This bibliographic study covers the origins and evolution of these cells. This review of NK cells includes synopsis of their well-known and evolving themes including their development, functions of cytokine production, anticancer cytotoxicity, clearing of viral infections and exhaustion. Within the liver, NK cells are enhanced in lymphocytes and possess distinctive phenotypic characters and useful properties, which contain tumour cytotoxicity and explicit cytokine profiles. NK cells, while providing innate immunity in the liver, play important roles in providing protection versus pathogens and tumours utilising their cytotoxicity and cytokine production. Accruing substantiation from the last few decades proposes that NK cells perform a vital role in regulating viral hepatitis and liver tumours. In addition, they contribute to the pathogenesis of liver damage including its inflammation. Understanding the description of hepatic NK cell functions has aided us in better understanding the pathogenesis of diseases of the liver and consequently divulging novel therapeutic goals for treating these illnesses.